Leveraging shared variation among traits for the discovery of genetic variants in complex phenotypes such as obesity
Fecha
2025-06-01
Profe guía
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Título de la revista
ISSN de la revista
Título del volumen
Editor
Wiley; The Obesity Society
ISBN
ISSN
1930-7381
ISSNe
1930-739X
Resumen
Identifying genetic variants associated with obesity is critical forunderstanding the role of genetics and its interaction with the envi-ronment in the regulation of body weight. Hundreds of genetic vari-ants have been identified so far, mostly associated with body massindex (BMI). Nevertheless, given the complex pathogenesis andthe evolving definition and diagnosis of obesity, exploring traitsbeyond BMI becomes crucial to advancing the field. Obesityresults from a prolonged positive energy balance, during which energyintake exceeds energy expenditure. Therefore, identifying geneticvariants associated with energy balance-related traits should provideadditional insight into the genetic basis of obesity.
Descripción
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Citación
Obesity a Research Journal, Vol. 33, N°7 (2025) p. 1025-1026.
Palabras clave
Obesity, Body massindex
Licencia
Atribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)