Impact of different exercise modalities on mitophagy in human skeletal muscle

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dc.contributor.authorMuñoz-Medina, Cristóbal
dc.contributor.authorCarriel-Nesvara, Alfonso
dc.contributor.authorBotella, Javier
dc.contributor.authorCastro-Sepulveda, Mauricio
dc.coverage.spatialUSA
dc.date.accessioned2025-12-29T15:58:11Z
dc.date.available2025-12-29T15:58:11Z
dc.date.issued2025
dc.description.abstractExercise induces profound mitochondrial adaptations in skeletal muscle, with different modalities uniquely influencing different branches of mitochondrial quality control (MQC). This review examines how endurance, resistance, and high-intensity interval training (HIIT) regulate mitophagy, the selective degradation of damaged mitochondria, in skeletal muscle (SkM). Research in rodents has shown that endurance exercise upregulates mitophagy primarily through the AMPK/PGC-1α signaling axis, promoting mitochondrial turnover and ensuring metabolic efficiency. In humans, high-intensity exercise increases mitophagy to a larger extent when compared to traditional endurance exercises. On the other hand, resistance exercise triggers alternative MQC mechanisms, including potential mitochondrial ejection. Collectively, these results suggest that mitophagy and MQC pathways are regulated in human SkM following exercise, but the specific molecular pathways seem to be specific to each exercise mode. Future studies should aim at disentangling the multiple mitophagy and MQC pathways in human SkM following exercise.
dc.description.sponsorshipProyecto investigación Fondecyt 11230548
dc.identifier.citationInternational Review of Cell and Molecular Biology, Vol. 399 (2025) p. 1-17
dc.identifier.doihttps://doi.org/10.1016/bs.ircmb.2025.10.005
dc.identifier.issn1937-6448
dc.identifier.orcidhttps://orcid.org/0000-0002-2270-299X
dc.identifier.orcidhttps://orcid.org/0009-0000-2165-0553
dc.identifier.urihttps://hdl.handle.net/20.500.12254/7423
dc.language.isoen
dc.publisherElsevier
dc.rightsAtribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/cl/
dc.subjectSkeletal muscle mitophagy
dc.subjectMitochondrial quality control
dc.subjectExercise training modalities
dc.titleImpact of different exercise modalities on mitophagy in human skeletal muscle
dc.typeArticle
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