Effects of an antioxidants cocktail on glucose metabolism at rest, during exercise, and during a glucose load in healthy young subjects

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dc.contributor.authorRodríguez, Ivan
dc.contributor.authorPaez Espinosa, Enma Verónica
dc.contributor.authorZbinden-Foncea, Hermann
dc.contributor.authorEcheverria, Francisca
dc.contributor.authorCastro-Sepulveda, Mauricio
dc.date.accessioned2024-11-28T15:49:49Z
dc.date.available2024-11-28T15:49:49Z
dc.date.issued2023-12-15
dc.description.abstractBackground: Reactive oxygen species (ROS) regulate glucose metabolism (GM) in skeletal muscle by improving the translocation of GLUT4. Antioxidant supplementation could block this physiological effect, altering glucose signaling during exercise. However, there is limited evidence in humans on whether antioxidant intake affects GM. Therefore, we aimed to determine the effect of an antioxidant cocktail (AOC) on GM at rest and during metabolic challenges. Methods: Ten healthy male subjects received AOC supplementation (1000 mg of Vitamin C, 600 IU of Vitamin E, and 600 mg of α-lipoic acid) or placebo (2.000 mg of talc) before two trials conducted 7 days apart. Trial 1: AOC 120 and 90 minutes before an endurance exercise (EEX) bout at 60 % of maximal oxygen uptake (VO2max); Trial 2: AOC 120 and 90 minutes before an oral glucose tolerance test (OGTT; 75 g glucose). Measurements of gas exchange and capillary blood samples were collected every 15 minutes during both trials. Results: AOC supplementation increased resting glucose levels (p<0.05). During Trial 1 (EEX), the AOC increased carbohydrate oxidation (CHOox) (p= 0.03), without effect in glucose blood levels. During Trial 2 (OGTT), the AOC supplementation had no significant effect on GM parameters. Conclusion: Acute supplementation with AOC increased resting glucose levels and CHOox during EEX in healthy subjects, with no effect on GM during the OGTT.
dc.identifier.citationRevista Chilena de Nutrición, Vol. 50, N°6 (2023) p. 1-9.
dc.identifier.doihttp://dx.doi.org/10.4067/S0717-75182023000600593
dc.identifier.issne0717-7518
dc.identifier.orcidhttp://orcid.org/0009-0009-8381-9217
dc.identifier.orcidhttp://orcid.org/0000-0002-9643-1037
dc.identifier.orcidhttp://orcid.org/0000-0002-2270-299X
dc.identifier.urihttp://hdl.handle.net/20.500.12254/3940
dc.language.isoen
dc.publisherSociedad Chilena de Nutrición, Bromatología y Toxicología
dc.rightsAtribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/cl/
dc.subjectGlucose metabolism
dc.subjectSubstrate oxidation
dc.subjectVitamin C
dc.subjectVitamin E
dc.titleEffects of an antioxidants cocktail on glucose metabolism at rest, during exercise, and during a glucose load in healthy young subjects
dc.title.alternativeEfecto de un cóctel de antioxidantes sobre el metabolismo de la glucosa en reposo, durante el ejercicio y durante una carga de glucosa en sujetos jóvenes sanos
dc.typeArticle
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