Automated and Interpretable Detection of Hippocampal Sclerosis in Temporal Lobe Epilepsy: AID-HS

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dc.contributor.authorRipart, Mathilde
dc.contributor.authorDeKraker, Jordan
dc.contributor.authorEriksson, Maria H
dc.contributor.authorPiper, Rory J
dc.contributor.authorGopinath, Siby
dc.contributor.authorParasuram, Harilal
dc.contributor.authorMo, Jiajie
dc.contributor.authorLikeman, Marcus
dc.contributor.authorCiobotaru, Georgian
dc.contributor.authorSequeiros-Peggs, Philip
dc.contributor.authorHamandi, Khalid
dc.contributor.authorXie, Hua
dc.contributor.authorCohen, Nathan T
dc.contributor.authorSu, Ting-Yu
dc.contributor.authorKochi, Ryuzaburo
dc.contributor.authorWang, Irene
dc.contributor.authorRojas-Costa, Gonzalo M
dc.contributor.authorGálvez, Marcelo
dc.contributor.authorParodi, Constanza
dc.contributor.authorRiva, Antonella
dc.contributor.authorD'Arco, Felipe
dc.contributor.authorMankad, Kshitij
dc.contributor.authorClark, Chris A
dc.contributor.authorCarbó, Adrián Valls
dc.contributor.authorToledano, Rafael
dc.contributor.authorTaylor, Peter
dc.contributor.authorNapolitano, Antonio
dc.contributor.authorRossi-Espagnet, Maria Camilla
dc.contributor.authorWillard, Anna
dc.contributor.authorSinclair, Benjamin
dc.contributor.authorPepper, Joshua
dc.contributor.authorSeri, Stefano
dc.contributor.authorDevinsky, Orrin
dc.contributor.authorPardoe, Heath R
dc.contributor.authorWinston, Gavin P
dc.contributor.authorDuncan, John S
dc.contributor.authorYasuda, Clarissa L
dc.contributor.authorScárdua-Silva, Lucas
dc.contributor.authorWalger, Lennart
dc.contributor.authorRüber, Theodor
dc.contributor.authorKhan, Aali R
dc.contributor.authorBaldeweg, Torsten
dc.contributor.authorAdler, Sophie
dc.contributor.authorWagstyl, Konrad
dc.contributor.authorMELD HS study group
dc.coverage.spatialEstados Unidos
dc.date.accessioned2026-08-04T19:02:55Z
dc.date.available2026-08-04T19:02:55Z
dc.date.issued2024-11-14
dc.description.abstractObjective: Hippocampal sclerosis (HS), the most common pathology associated with temporal lobe epilepsy (TLE), is not always visible on magnetic resonance imaging (MRI), causing surgical delays and reduced postsurgical seizure-freedom. We developed an open-source software to characterize and localize HS to aid the presurgical evaluation of children and adults with suspected TLE. Methods: We included a multicenter cohort of 365 participants (154 HS; 90 disease controls; 121 healthy controls). HippUnfold was used to extract morphological surface-based features and volumes of the hippocampus from T1-weighted MRI scans. We characterized pathological hippocampi in patients by comparing them to normative growth charts and analyzing within-subject feature asymmetries. Feature asymmetry scores were used to train a logistic regression classifier to detect and lateralize HS. The classifier was validated on an independent multicenter cohort of 275 patients with HS and 161 healthy and disease controls. Results: HS was characterized by decreased volume, thickness, and gyrification alongside increased mean and intrinsic curvature. The classifier detected 90.1% of unilateral HS patients and lateralized lesions in 97.4%. In patients with MRI-negative histopathologically-confirmed HS, the classifier detected 79.2% (19/24) and lateralized 91.7% (22/24). The model achieved similar performances on the independent cohort, demonstrating its ability to generalize to new data. Individual patient reports contextualize a patient's hippocampal features in relation to normative growth trajectories, visualise feature asymmetries, and report classifier predictions. Interpretation: Automated and Interpretable Detection of Hippocampal Sclerosis (AID-HS) is an open-source pipeline for detecting and lateralizing HS and outputting clinically-relevant reports.
dc.identifier.citationAnnals of Neurology, Vol. 97, N°. 1 (2024) pp. 62-75
dc.identifier.doihttps://doi.org/10.1002/ana.27089
dc.identifier.issn0364-5134
dc.identifier.issn1531-8249
dc.identifier.orcidhttps://orcid.org/0000-0002-6228-2678
dc.identifier.urihttps://hdl.handle.net/20.500.12254/7689
dc.language.isoen
dc.publisherWiley Periodicals LLC
dc.rightsAtribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/cl/
dc.titleAutomated and Interpretable Detection of Hippocampal Sclerosis in Temporal Lobe Epilepsy: AID-HS
dc.typeArticle
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