Risk of cervical metastasis in primary parotid gland malignancies: A Yo-IFOS multicenter retrospective longitudinal study: a Yo-IFOS multicenter retrospective longitudinal study

Vista sencilla de ítem
dc.contributor.authorKalfert, David
dc.contributor.authorPalacios-Garcia, Jose
dc.contributor.authorTel, Alessandro
dc.contributor.authorVaira, Luigi Angelo
dc.contributor.authorManiaci, Antonino
dc.contributor.authorSilva-Figueroa, Angelica
dc.contributor.authorBoscolo-Rizzo, Paolo
dc.contributor.authorSalzano, Giovanni
dc.contributor.authorConsorti, Giuseppe
dc.contributor.authorEnver, Necati
dc.contributor.authorDequanter, Didier
dc.contributor.authorMelkane, Antoine
dc.contributor.authorCobanoglu, H. Bengu
dc.contributor.authorPetrocelli, Marzia
dc.contributor.authorAndueza-Guembe, Maider
dc.contributor.authorLentini, Mario
dc.contributor.authorToledo-Villegas, Karina
dc.contributor.authorTirelli, Giancarlo
dc.contributor.authorTramontano, Sara
dc.contributor.authorCirignaco, Giulio
dc.contributor.authorLechien, Jerome R.
dc.contributor.authorİncaz, Sefa
dc.contributor.authorDe Riu, Giacomo
dc.coverage.spatialEstados Unidos
dc.date.accessioned2026-05-28T14:24:37Z
dc.date.available2026-05-28T14:24:37Z
dc.date.issued2026-05-08
dc.description.abstractBackground: Cervical lymph node metastasis is a major adverse prognostic factor in primary parotid gland malignancies. However, the incidence, level-specific distribution, and independent predictors of nodal metastasis remain incompletely defined in large contemporary multicenter cohorts. Methods: A retrospective longitudinal multicenter study was conducted across 17 tertiary referral centers. Adult patients with histopathologically confirmed primary parotid gland carcinoma who underwent parotidectomy with concurrent neck dissection were included. The primary outcome was pathologically confirmed cervical lymph node metastasis. Secondary outcomes included level-specific nodal distribution, identification of independent risk factors, overall survival (OS), and disease-specific survival (DSS). Results: A total of 380 patients were included. Pathological cervical lymph node metastasis was identified in 94 patients (24.7%). Metastases most frequently involved Level II (IIa 17.1%; IIb 11.1%). Salivary duct carcinoma demonstrated the highest rate of nodal metastasis (58.7%). On multivariate analysis, high histological grade and lymphovascular invasion (LVI) were independent predictors of nodal metastasis (p<0.05). Five-year OS for the entire cohort was 64.4%. Patients with nodal metastasis had significantly worse survival compared with node-negative patients (p<0.001). Conclusions: Cervical lymph node metastasis occurs in approximately one-quarter of surgically staged primary parotid gland malignancies and predominantly involves Levels II–III. High-grade histology and LVI independently predict nodal involvement. These findings support a risk-adapted approach to elective neck management ased on histological and pathological risk stratification.
dc.description.embargo2027-05-19
dc.identifier.citationHead & Neck (2026) pp. 1–11
dc.identifier.doihttps://doi.org/10.1002/hed.70320
dc.identifier.issn1043-3074
dc.identifier.issne1097-0347
dc.identifier.orcidhttps://orcid.org/0000-0002-4992-7072
dc.identifier.urihttps://hdl.handle.net/20.500.12254/7599
dc.language.isoen
dc.publisherHead & Neck
dc.relation.ispartofseries0; 0
dc.rightsAtribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/cl/
dc.subjectcervical lymph node metastasis
dc.subjecthistological grade
dc.subjectlymphovascular invasion
dc.subjectneck dissection
dc.subjectparotid gland carcinoma
dc.subjectprognostic factors
dc.subjectsalivary gland malignancy
dc.titleRisk of cervical metastasis in primary parotid gland malignancies: A Yo-IFOS multicenter retrospective longitudinal study: a Yo-IFOS multicenter retrospective longitudinal study
dc.typeArticle
Archivos
Bloque original
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
Articulo. Head Neck - 2026 - Risk of Cervical Metastasis in Primary Parotid Gland Malignancies A YoIFOS.pdf
Tamaño:
586.05 KB
Formato:
Adobe Portable Document Format
Descargar
Bloque de licencias
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
347 B
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar
Colecciones
Artículos de Revistas