Effect of supervised resistance training on arm volume, quality of life and physical perfomance among women at high risk for breast cancer-related Lymphedema: A study protocol for a randomized controlled Trial (STRONG-B)

Objectives: To determine the preventive effects of supervised resistance training on arms volume, quality of life, physical performance, and handgrip strength in Chilean women at high risk for breast cancer-related lymphedema (BCRL) undergoing chemotherapy. Design: Randomized control trial. Participants: One hundred and six women at high risk for breast cancer-related lymphedema aged 18 to 70 years. Interventions: Participants will be randomized into two groups: [a] intervention, who will receive 12 weeks of supervised resistance training (STRONG-B) during adjuvant chemotherapy; and [b] control, who will receive education to promote lymphatic and venous return, maintain range of motion, and promote physical activity. Main Outcome Measures: The primary outcome will be arms volume measured with an optoelectric device (perometer NT1000). Secondary outcomes will be quality of life, handgrip strength, and physical performance. Primary and secondary outcomes will be measured at baseline, just after the intervention, and 3 and 6 months after. Statistical analysis will be performed following intention-to-treat and per-protocol approaches. The treatment effect will be calculated using linear mixed models. Discussion: The STRONG-B will be a tailored supervised resistance training that attempts to prevent or mitigate BCRL in a population that, due to both intrinsic and extrinsic factors, will commonly suffer from BCRL. Clinical Trial Registration: [https://clinicaltrials.gov/ct2/show/NCT04821609], identifier NCT04821609.

item.page.sponsorship

The study is funded by ANID+FONDEF/XVII Concurso Nacional de Proyectos de Investigación y Desarrollo en Salud, Fonis (SA20I0060). This work is part of KR-P’s doctoral work at the Clinical Medicine and Public Health Doctoral Studies of the University of Granada, Spain.

Citation

Ram´ırez-Parada K, Lopez-Garzon M, Sa´ nchez-Rojel C, Petric-Guajardo M, Alfaro-Barra M, Fernandez-Verdejo R, Reyes-Ponce A, Merino-Pereira G and Cantarero-Villanueva I (2022) Effect of Supervised Resistance Training on Arm Volume, Quality of Life and Physical Perfomance Among Women at High Risk for Breast Cancer-Related Lymphedema: A Study Protocol for a Randomized Controlled Trial (STRONG-B). Front. Oncol. 12:850564. doi: 10.3389/fonc.2022.850564

Collections

Artículos de Revistas

Full item page