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A mutation in desmin makes skeletal muscle less vulnerable to acute muscle damage after eccentric loading in rats

Langer, Henning T.; Mossakowski, Agata A.; Avey, Alec M.; Wohlgemuth, Ross P.; Smith, Lucas R.; Zbinden-Foncea, Herman; Baar, Keith (Wiley Open Access, 2021-09-01)

Desminopathy is the most common intermediate filament disease in humans. The most frequent mutation causing desminopathy in patients is a R350P DES missense mutation. We have developed a rat model with an analogous mutation ...