Carvajal, Cristian A.Tapia-Castillo, AlejandraUslar, ThomasVaidya, AnandPérez, Jorge A.Baudrand, ReneFardella, Carlos E.2025-11-272025-11-272025-11-12Nature Reviews Endocrinology, (2025) p. 1-2.1759-5029https://hdl.handle.net/20.500.12254/7374Non-classic apparent mineralocorticoid excess is an underrecognized cause of low-renin hypertension, which is often misdiagnosed as essential hypertension. This condition challenges traditional classifications and highlights the need for mechanism-based diagnostics and medical care. Hypertension remains a leading contributor to global cardiovascular morbidity and mortality. It has a high prevalence, low rate of identifiable causes and is frequently resistant to conventional therapy. Hypertension is traditionally classified as ‘essential’ and multifactorial; however, up to one-third of patients have hypertension with a low-renin phenotype . This subtype has been largely attributed to primary aldosteronism, yet emerging data suggest a broader and more complex spectrum of mineralocorticoid receptor (MR) overactivation. Non-classic apparent mineralocorticoid excess (NC-AME) is one of several overlooked contributors to low-renin hypertension; NC-AME might account for a meaningful proportion of patients who have been misclassified as having essential hypertension.enAtribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)Apparent mineralocorticoid excessHypertensionLow-renin hypertensionArticlehttps://orcid.org/0000-0002-6081-1468https://doi.org/10.1038/s41574-025-01209-61759-5037