Garrido, MauricioBordagaray, María JoséSchweitzer, CatalinaLucero-Mora, JoaquínReyes, MontserratPellegrini, ElizabethHernández-Ríos, PatriciaFernández, AlejandraHernández, Marcela2024-02-012024-02-012024-01-05International Endodontic Journal (2024) p. 1–10.0143-2885http://hdl.handle.net/20.500.12254/3607Aim: To determine the systemic inflammatory burden, including hsCRP and its monomeric forms, in patients with apical lesions of endodontic origin treated with root canal treatment (RCT). Methodology: Prospective pre-/post-study. Apical periodontitis (AP) individuals aged 16–40 were included (N=29). Individuals received RCT and were followed at 1 and 6months. Fasting blood samples were obtained. Apical lesions of endodon tic origin (ALEO) diameter (mm), and periapical index (PAI), were recorded. The serum concentrations of total hsCRP were determined by turbidimetry. Tumour necrosis factor (TNF)-α, interleukin (IL)-6, IL-10, IL-1β, and soluble (s) E-selectin were assessed by Multiplex assay. Additionally, mCRP forms were determined in the serum of AP patients with a baseline moderate to high cardiovascular risk based on hsCRP stratification (hsCRP ≥1mg/L) by immunowestern blot (n=15). Also, CRP isoforms were explored in ALEOs from AP individuals (n=4). Data were analysed with StataV16. Results: Periapical index and ALEO sizes were reduced at both follow-up visits after RCT (p<.05). Serum levels of TNF-α, IL-6, IL-10, IL-1β, and sE-selectin did not show significant differences. CRP was borderline reduced at 1month (p=.04); however, in AP individuals at cardiovascular risk (hsCRP≥1mg/L), hsCRP and its monomeric isoform significantly decreased at 1 and 6months (p<.05). Conclusions: High-sensitivity CRP and mCRP are reduced after RCT in AP indi viduals at cardiovascular risk.enAtribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)Cardiovascular diseasesC-reactive proteinHeart disease risk factorPeriapical periodontitisArticlehttps://orcid.org/0000-0002-8554-7181https://doi.org/10.1111/iej.140291365-2591