Leveraging shared variation among traits for the discovery of genetic variants in complex phenotypes such as obesity

Fernández-Verdejo, RodrigoHughes, DavidRavussin, Eric2025-07-102025-07-102025-06-01Obesity a Research Journal, Vol. 33, N°7 (2025) p. 1025-1026.1930-7381https://hdl.handle.net/20.500.12254/4195Identifying genetic variants associated with obesity is critical forunderstanding the role of genetics and its interaction with the envi-ronment in the regulation of body weight. Hundreds of genetic vari-ants have been identified so far, mostly associated with body massindex (BMI). Nevertheless, given the complex pathogenesis andthe evolving definition and diagnosis of obesity, exploring traitsbeyond BMI becomes crucial to advancing the field. Obesityresults from a prolonged positive energy balance, during which energyintake exceeds energy expenditure. Therefore, identifying geneticvariants associated with energy balance-related traits should provideadditional insight into the genetic basis of obesity.enAtribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)ObesityBody massindexLeveraging shared variation among traits for the discovery of genetic variants in complex phenotypes such as obesityArticlehttps://orcid.org/0000-0002-5948-2281https://doi.org/10.1002/oby.243131930-739X