Valenzuela-Fuenzalida, Juan JoséSalazar-Arancibia, TamaraLaborie-Reyes, BenjaminRodríguez-Ortiz, FranciscoLoaiza Giraldo, Jessica PaolaSalgado, CristianNova-Baeza, PabloOrellana-Donoso, MathiasMoya, Maria P.Bruna Mejías, AlejandroCifuentes-Suazo, GloriaOyanedel-Amaro, GustavoValenti, Vitor E.Sanchis-Gimeno, Juan Alberto2026-09-282026-09-282026-10Clinical Nutrition ESPEN, Vol. 75 (2026) pp. 1-15https://hdl.handle.net/20.500.12254/7744Non-alcoholic fatty liver disease (NAFLD), recently redefined as metabolic dysfunction-associated steatotic liver disease (MASLD), is a leading cause of chronic liver disease worldwide. The Mediterranean diet (MD) is widely recommended for its metabolic benefits, but its specific impact on NAFLD/MASLD outcomes remains variable across trials. This systematic review and meta-analysis evaluated the effect of the Mediterranean diet on liver steatosis, liver enzymes, and metabolic markers in patients with NAFLD/MASLD. Larger, high-quality randomized trials with standardized dietary definitions and longer follow-up are required to clarify its therapeutic role in NAFLD/MASLD.Atribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)Mediterranean dietNAFLDMASLDNon-alcoholic fatty liver diseaseMetabolic dysfunction-associated steatotic liver diseaseSystematic reviewMeta-analysisRandomized controlled trialsArticlehttps://orcid.org/0000-0002-1781-062Xhttps://doi.org/10.1016/j.clnesp.2026.1050172405-4577