Baudrand, ReneCarvajal, CristianTapia-Castillo, AlejandraUslar, ThomasFardella, Carlos2026-02-232026-02-232025En: Padiporn Limumpornpetch, Paul M. Stewart (editores). Encyclopedia of Endocrine Diseases. Elsevier, 2019. p. 638-6439780128122006https://hdl.handle.net/20.500.12254/7457Hypertension is highly prevalent in the general population. Up to 1/3 of patients display low-renin levels due to aldosterone-mediated mineralocorticoid receptor (MR) activation or cortisol-mediated MR activation. The spectrum of cortisol-mediated MR activation includes the classic apparent mineralocorticoid excess (AME), Cushing syndrome or milder (non-classic) forms of AME, the latter with a much higher prevalence and subtle phenotype. Classic AME is a rare autosomal recessive disorder caused by the presence of a severe dominant autosomal deficiency of 11bHSD2 gene. Non-classic -AME (NC-AME) is mainly associated with partial 11bHSD2 deficiency due to milder genetic variations or epigenetic modifications plus potential actions of endogenous or exogenous inhibitors. Treatment aims to ameliorate MR activation with low-sodium diet and MR antagonists.enAtribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)Book chapterhttps://orcid.org/0000-0002-6081-1468https://doi.org/10.1016/B978-0-12-801238-3.64338-6