Castro-Sepulveda, Mauricio2025-12-192025-12-192025-12Trends in Endocrinology & Metabolism, Vol. 10, N° 10 (2025) p. 2-41879-3061https://hdl.handle.net/20.500.12254/7420Emerging evidence suggests an interplay between the molecular clock and mitochondrial dynamics in skeletal muscle. In this Forum article, we hypothesize that exercise, as a metabolic challenge, provides a powerful physiological model to investigate the clock–mitochondria axis and its regulatory role in muscle function and metabolic health in humans.enAtribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)molecular clockmitochondrial dynamicsskeletal muscleArticlehttps://orcid.org/0000-0002-2270-299Xhttps://doi.org/10.1016/j.tem.2025.11.001