Rivera-Tovar, Pamela RaquelTorres, María DoloresCamilo, ConradoMariotti-Celis, María SaloméDomínguez, HerminiaPérez-Correa, José Ricardo2021-12-142021-12-142021-03-29Food Chemistry, Vol. 357, September, 129729 (2021) p. 1-110308-8146http://hdl.handle.net/20.500.12254/2098Multi-response optimization of hot pressurized liquid extraction (HPLE) was applied for the first time to obtain maqui (Aristotelia chilensis [Mol.] Stuntz) leaf extracts. The total polyphenol content (TPC), the antioxidant capacity (AC) as well as the total polyphenol purity of the maqui leaf extracts were accurately predicted (RSD < 8%) at the evaluated extraction scales. The optimum HPLE conditions that prioritized TPC and AC equally (OPT1) recovered ~3 times more TPC (205.14 mg GAE/g leaves) than maqui leaf extracts obtained by maceration, while the extract that prioritized purity over TPC and AC presented the highest purity (36.29%) and an EC50 ~3 times lower than currently reported values. It was found by multi-response optimization that maqui leaves and HPLE are among the best natural sources and extraction techniques, respectively, to recover protocatechuic acid, quercetin, and catechin.enAtribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)Number of cyclesDesirability function (DF)Extract’s polyphenol purityPolyphenol extraction yieldResponse surface methodology (RSM)Accelerated solvent extraction (ASE)Artículohttps://orcid.org/0000-0003-1357-812Xhttps://doi.org/10.1016/j.foodchem.2021.129729