Rivera-Tovar, Pamela RaquelTorres, María DoloresCamilo, ConradoMariotti-Celis, María SaloméDomínguez, HerminiaPérez-Correa, José Ricardo2021-12-142021-12-142021-03-29Food Chemistry, Vol. 357, September, 129729 (2021) p. 1-110308-8146https://hdl.handle.net/20.500.12254/2098Multi-response optimization of hot pressurized liquid extraction (HPLE) was applied for the first time to obtain maqui (Aristotelia chilensis [Mol.] Stuntz) leaf extracts. The total polyphenol content (TPC), the antioxidant capacity (AC) as well as the total polyphenol purity of the maqui leaf extracts were accurately predicted (RSD < 8%) at the evaluated extraction scales. The optimum HPLE conditions that prioritized TPC and AC equally (OPT1) recovered ~3 times more TPC (205.14 mg GAE/g leaves) than maqui leaf extracts obtained by maceration, while the extract that prioritized purity over TPC and AC presented the highest purity (36.29%) and an EC50 ~3 times lower than currently reported values. It was found by multi-response optimization that maqui leaves and HPLE are among the best natural sources and extraction techniques, respectively, to recover protocatechuic acid, quercetin, and catechin.engAcceso abiertoNumber of cyclesDesirability function (DF)Extract’s polyphenol purityPolyphenol extraction yieldResponse surface methodology (RSM)Accelerated solvent extraction (ASE)ArtículoAtribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)https://orcid.org/0000-0001-8064-3070https://orcid.org/0000-0003-1357-812Xhttps://doi.org/10.1016/j.foodchem.2021.129729